A growth hormone releasing hormone (GHRH) analog that was previously FDA-approved (as Geref, discontinued) and is now most often used off-label/compounded to support the body's natural GH production, especially in age-related GH decline.
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What Is Sermorelin?
TL;DR: Sermorelin is a GHRH analog with a genuine history as an FDA-approved drug (Geref), now mostly used off-label through compounding pharmacies or research-chemical channels to support natural GH release, especially for age-related decline.
Sermorelin is a peptide made up of the first 29 amino acids of naturally occurring growth hormone releasing hormone (GHRH) — the shortest fragment shown to retain full biological activity. It was FDA-approved in the 1990s under the brand name Geref for diagnosing and treating growth hormone deficiency before the manufacturer discontinued the product commercially.
How It Works
Sermorelin binds to GHRH receptors in the pituitary gland, prompting it to produce and release growth hormone in a pattern that closely mirrors the body’s own natural GH pulses — a key distinction from taking synthetic HGH directly, which bypasses the pituitary gland’s own regulatory feedback loop.
Who Uses It and Why
Sermorelin has a somewhat different user base than ipamorelin or CJC-1295 alone: it’s the GH secretagogue most likely to be encountered through an actual hormone-replacement clinic with lab monitoring, in addition to being available through the same research-chemical channels as other peptides on this list.
How Sermorelin Is Typically Used
Common forms
- Subcutaneous injection, typically before bed
Typical protocol discussed in the community
Where prescribed by hormone clinics, doses commonly cited are in the range of 200–300 mcg per night. Community/research-chemical protocols cite similar ranges. Because sermorelin has a short half-life, it's almost always dosed as a single nightly injection rather than split doses.
Notes
Because a legitimate, prescribable compounded version exists (unlike many peptides in this category), sermorelin is one of the few GH secretagogues where working with a hormone-focused physician for lab-monitored use is a realistic, lower-risk option compared to unsupervised sourcing.
Supplied as a lyophilized powder in most non-prescription vials — see our BAC water & reconstitution guide before mixing a vial.
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